In 2008, she was the second actor to be cast in the CW series 90210, portraying antiheroine Naomi Clark. Initially, the part of Clark was conceived as a supporting role. By the end of the first season, however, various media outlets had begun referring to AnnaLynne McCord as the series' lead.
Apart from acting, she has also contributed to charities in her free time, and has been labeled by the Look to the Stars organization as "one of the strongest young female philanthropists standing up in Hollywood and fighting for the charities she believes in." In 2009, AnnaLynne McCord was nominated for a Teen Choice Award, and received the Hollywood Life Young Hollywood Superstar of Tomorrow award. For the role of Naomi Clark, she won a Breakthrough of the Year Award in the category of "Breakthrough Standout Performance" in 2010.